E-Journal ACS

Anno: 2021Designing out PXR Activity on Drug Discovery Projects: A Review of Structure–Based Methods, Empirical and Computational Approaches ; 2021, Vol. 64, n. 10, pp. 6413-6522
Novel Approaches, Drug Candidates, and Targets in Pain Drug Discovery ; 2021, Vol. 64, n. 10, pp. 6523-6548
Glutaminyl Cyclase, Diseases, and Development of Glutaminyl Cyclase Inhibitors ; 2021, Vol. 64, n. 10, pp. 6549-6565
Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH–Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1 H)–Quinolones with Single Dose Cures ; 2021, Vol. 64, n. 10, pp. 6581-6595
Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure–Activity Relationships ; 2021, Vol. 64, n. 10, pp. 6621-6633
Synthesis, Structure–Activity Relationships, and in Vivo Evaluation of Novel Tetrahydropyran–Based Thiodisaccharide Mimics as Galectin–3 Inhibitors ; 2021, Vol. 64, n. 10, pp. 6634-6655
Novel Mixed NOP/Opioid Receptor Peptide Agonists ; 2021, Vol. 64, n. 10, pp. 6656-6669
Disrupting Tryptophan in the Central Hydrophobic Region Selectively Mitigates Immunomodulatory Activities of the Innate Defence Regulator Peptide IDR–1002 ; 2021, Vol. 64, n. 10, pp. 6696-6705
Re–emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery ; 2021, Vol. 64, n. 10, pp. 6706-6719
New Dibenzoquinoxalines Inhibit Triple–Negative Breast Cancer Growth by Dual Targeting of Topoisomerase 1 and the c–MYC G–Quadruplex ; 2021, Vol. 64, n. 10, pp. 6720-6729
Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA–Encoded Chemical Library Screening ; 2021, Vol. 64, n. 10, pp. 6730-6744
Structure–Guided Discovery of Potent and Selective DYRK1A Inhibitors ; 2021, Vol. 64, n. 10, pp. 6745-6764
High Cytotoxic Effect by Combining Copper–64 with a NOTA–Terpyridine Platinum Conjugate ; 2021, Vol. 64, n. 10, pp. 6765-6776
Developing a Novel Anticancer Gold(III) Agent to Integrate Chemotherapy and Immunotherapy ; 2021, Vol. 64, n. 10, pp. 6777-6791
Photostable Platinated Bacteriochlorins as Potent Photodynamic Agents ; 2021, Vol. 64, n. 10, pp. 6792-6801
Fragment–Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model ; 2021, Vol. 64, n. 10, pp. 6814-6826
Rationally Designed Protein–Based Inhibitor of α–Synuclein Fibrillization in Cells ; 2021, Vol. 64, n. 10, pp. 6827-6837
Syntheses of Morpholine–Based Nucleotide Analogs for Hepatic siRNA Targeting and Stabilization ; 2021, Vol. 64, n. 10, pp. 6838-6855
Discovery of New Imidazo[2,1– b]thiazole Derivatives as Potent Pan–RAF Inhibitors with Promising in Vitro and in Vivo Anti–melanoma Activity ; 2021, Vol. 64, n. 10, pp. 6877-6901
Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route ; 2021, Vol. 64, n. 10, pp. 6902-6923
Orally Active Peptide Vector Allows Using Cannabis to Fight Pain while Avoiding Side Effects ; 2021, Vol. 64, n. 10, pp. 6937-6948
Thiazolidinedione "magic Bullets" Simultaneously Targeting PPARγand HDACs: Design, Synthesis, and Investigations of their in Vitro and in Vivo Antitumor Effects ; 2021, Vol. 64, n. 10, pp. 6949-6971
Halting the Spread of Herpes Simplex Virus–1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand ; 2021, Vol. 64, n. 10, pp. 6972-6984
Synthesis and Evaluation of PPARδAgonists That Promote Osteogenesis in a Human Mesenchymal Stem Cell Culture and in a Mouse Model of Human Osteoporosis ; 2021, Vol. 64, n. 10, pp. 6996-7032
Neuroactive Type–A γ–Aminobutyric Acid Receptor Allosteric Modulator Steroids from the Hypobranchial Gland of Marine Mollusk, Conus geographus ; 2021, Vol. 64, n. 10, pp. 7033-7043