Chemical Processes Involving 18–Crown–6–Ether in Activated Noncovalent Complexes with Protonated Peptides / Marwa Abdelmouleh; Mathieu Lalande; Edith Nicol; Gilles Frison; Guillaume van der Rest; Jean–Christophe Poully
Si trova su / Altri legami
© 2021 Wiley–VCH GmbHThese last decades, it has been widely assumed that 18–crown–6–ether (CE) plays a spectator role during the chemical processes occurring in isolated host–guest complexes between peptides or proteins and CE after activation in mass spectrometers. Our present experimental and theoretical results challenge this hypothesis by showing that CE can abstract a proton or a protonated molecule from protonated peptides after activation by collisions in argon or electron capture/transfer. Furthermore, thanks to comparison between experimental and calculated values of collision cross–sections, we demonstrate that CE can change binding site after electron transfer. We also propose detailed mechanisms for these processes.
