Si trova su / Altri legami
© 2021 American Chemical Society.In this paper, the solubility of 2–amino–5–chloro–3–methylbenzoic acid under 0.1 MPa atmospheric pressure and temperature T = 278.15–323.15 K was determined by gravimetric analysis. Considering the safety and the cost of solvents, we selected the following 10 pure solvents and three binary mixed solvents: methanol, ethanol, n–butanol, acetone, acetonitrile, ethyl acetate, n–propanol, isopropanol, xylene, and n–hexane (n–hexane + acetone), (acetonitrile + acetone), and (methanol + acetone). The aim is to find suitable solvent systems for the recrystallization of 2–amino–5–chloro–3–methylbenzoic acid. The results indicate that the solubility of 2–amino–5–chloro–3–methylbenzoic acid is positively correlated with temperature, and the solubility of 2–amino–5–chloro–3–methylbenzoic acid is better in acetone. The modified Apelblat model, the Buchowski–Ksiazaczak λh model, the Redlich–Kister (CNIBS/R–K) model, and the Jouyban–Acree model were used to fit the solubility data of 2–amino–5–chloro–3–methylbenzoic acid in different solvents, and the experimental values were in good agreement with the calculated values. By comparing the four models, the modified Apelblat model was found to have a good correlation in pure solvents, and the Redlich–Kister (CNIBS/R–K) model was more suitable than the other two models in binary mixed solvents.
