Si trova su / Altri legami
© 2021 American Chemical Society and American Society of Pharmacognosy.Twenty–four diterpenoids (1–24), classified into nine diverse carbon skeletal types, 8–nor–7(8→14),9(8→7)–di–abeo–abietane (1, 2, and 13), 7(8→14),9(8→7)–di–abeo–abietane (3 and 4), 6–nor–6,7–seco–abietane (5 and 6), 6,7–seco–abietane (7 and 11), 9,10–seco–abietane (8), abietane (9, 10, and 14–21), 11(9→8),20(10→11)–di–abeo–abietane (12), 15(13→12)–abeo–abietane (22 and 23), and 4,5–seco–20(10→5)–abeo–abietane (24), respectively, were isolated from the roots of Salvia deserta. The structures of 10 new diterpenoids, named salviadesertins A–J (1–10), were elucidated by spectroscopic data interpretation, quantum–chemical calculations including calculated 13C NMR–DP4+ analysis and electronic circular dichroism as well as X–ray crystallography analysis. The absolute configurations of compounds 1–3, 7, 14, and 22 were defined by single–crystal X–ray diffraction analysis. All the isolated diterpenoids 1–24 were evaluated for their cytotoxicity against five cancer cell lines, and 6–hydroxysalvinolone (14) showed micromolar potencies against MCF–7, A–549, SMMC–7721, and HL–60 cells, whereas the other diterpenoids were inactive (half–maximal inhibitory concentration greater than 10.0 μM).
