Motobamide, an Antitrypanosomal Cyclic Peptide from a Leptolyngbya sp. Marine Cyanobacterium / Hiroki Takahashi; Arihiro Iwasaki; Naoaki Kurisawa; Ryota Suzuki; Ghulam Jeelani; Teruhiko Matsubara; Toshinori Sato; Tomoyoshi Nozaki; Kiyotake Suenaga
Si trova su / Altri legami
© 2021 American Chemical Society and American Society of Pharmacognosy.Motobamide (1), a new cyclic peptide containing a C–prenylated cyclotryptophan residue, was isolated from a marine Leptolyngbya sp. cyanobacterium. Its planar structure was established by spectroscopic and MS/MS analyses. The absolute configuration was elucidated based on a combination of chemical degradations, chiral–phase HPLC analyses, spectroscopic analyses, and computational chemistry. Motobamide (1) moderately inhibited the growth of bloodstream forms of Trypanosoma brucei rhodesiense (IC50 2.3 μM). However, it exhibited a weaker cytotoxicity against normal human cells (IC50 55 μM).
